Synthetic Approaches towards Peptidomimetic Design

• Modified peptides: these molecules contain relatively small modifications that do not modify the peptide bond, and thus they still possess a chemical structure of peptide nature. • Pseudopeptides: in these compounds partial modifications of either peptide bonds or side-chains are introduced, contributing to the generation of molecules possessing a chemical structure of only partial peptide nature. • Peptidomimetics: these compounds do not possess any amide bond of the original peptide, and the structural resemblance is related to the pharmacophore and to the pharmacological activity of the bioactive peptide conformation.